Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity

KE Larrimore, M Barcus, L Kannan, Y Gao… - Chemico-biological …, 2013 - Elsevier
Cocaine addiction affects millions of people with disastrous personal and social
consequences. Cocaine is one of the most reinforcing of all drugs of abuse, and even those
who undergo rehabilitation and experience long periods of abstinence have more than 80%
chance of relapse. Yet there is no FDA-approved treatment to decrease the likelihood of
relapse in rehabilitated addicts. Recent studies, however, have demonstrated a promising
potential treatment option with the help of the serum enzyme butyrylcholinesterase (BChE) …
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